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KMID : 0352720080320010039
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Journal of Ginseng Research
2008 Volume.32 No. 1 p.39 ~ p.47
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Mechanisms of Korean red ginseng and herb extracts(KTNG0345) for anti-wrinkle activity
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Lee Seong-Kye
Hwang Eui-Il
Koo Bon-Suk
Han Gyeong-Ho
Chung Jin-Ho
Lee Min-Jung
Kim Na-Mi
So Seung-Ho
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Abstract
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UV irradiation causes skin-aging involving coarse wrinkles, thickening, dyspigmentation, and rough skin surface. These phenomena in complex skin tissue is controlled with receptor of cell surface growth factor and cytokine receptors. The activation of receptors induces multiple downstream signaling pathways including expression of MMPs (matrix metalloproteinases). This study was aimed to elucidate the mechanism for anti-wrinkle activity of Korean red ginseng, Torilis fructus and Corni fructus mixture (KTNG0345). In this animal study, we have investigated decreasing effects of Korean red ginseng mixture on MMP-3 synthesis through diminishing signaling that express MMP-1, -3, and -9. c-Jun and c-fos as a component of transcription factor AP-1 (activator protein-1) were analyzed the expression level using real time PCR and western blotting. c-Jun was decreased dose dependent manner both gene and protein level where as cfos was not changed. In upstream, JNK and PAK was not changed, but p38 was decreased in down stream. MMP-3, final product in this pathway was significantly decreased in dose dependent manner. These results suggest that Korean red ginseng mixture have a anti-wrinkle activity through mediated MMPs expression pathway.
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KEYWORD
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anti-wrinkle, matrix metalloproteinase-3, AP-1, p38, Korean red ginseng
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